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Meanwhile, tumor cells can increase FAO levels by upregulating CPT1 expression, and high levels of FAO can promote EMT [100, 132, 133] and foster M2 macrophage polarization, which subsequently leads to the secretion of pro-inflammatory cytokines such as IL-1, thereby augmenting tumor cell motility and proliferative capacity [134]

This is slower than popping an ibuprofen, but peptides actually heal the damaged tissue causing pain rather than just masking symptoms

Acute administration of capsaicin increases resting energy expenditure in young obese subjects without affecting energy intake, appetite, and circulating levels of orexigenic/anorexigenic peptides